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No, if you intend to use Biodiesel. The FUEL has been converted to have the same physical propeties as petroleum diesel so it will run in any diesel engine. So you don't need to convert your car.

Yes, if you intend to use SVO (straight veggie oil). Straight Vegetable Oil is too viscous to work properly in a modern-day diesel engine, so the CAR needs to be modified. The modification can take many forms, but the basic idea is to heat the oil to bring its viscosity down before it passes through the injector.

There ARE 2 things to look out for mechanically when you switch from dinodiesel to Biodiesel. Both are related to biodiesel's excellent solvent abilities.

1) Clogged Fuel filter- This is a transitional issue so it will happen only once, possibly twice when you make the switch from petroleum to biodiesel. Because biodiesel is a better solvent than petroleum diesel, it will clean out all the deposits that petroleum has left in your fuel lines. This is a good thing. Just be aware that all that old petroleum gunk that will end up in your fuel filter. When you start to notice performance issues like decreased acceleration or hard starts (it could be in 2 weeks or 2 years) you'll need to change out your filter. It's a cheap and easy thing for your local mechanic to handle if you don't want to do it yourself.

2) Rubber lines and gaskets. This only applies to cars older than 1994. If you have an older car (pre-1994), it has rubber components like fuel lines, seals, and gaskets. Biodiesel acts as a solvent on rubber and can soften and degrade it over time. Again, this is not something to panic about. Have your local mechanic point out the fuel lines on your engine to you. Every now and then take a look at them. If you see what look like beads of sweat on the lines, it's time to replace them with lines made of Viton- a synthetic rubber that won't deteriorate from biodiesel use. You can also pre-empt any issues by changing over to viton right away. Again, a cheap and easy fix for your mechanic.